The new PMC design is here! Cobalt residing at the center of cobalt-corrinoid complexes is essential for the synthesis of vitamin B12. A new study found that honey consumption was linked to lower fasting blood sugar levels. Spice it up: cinnamon lowers blood sugar levels. J Bone Joint Surg Am. The site is secure. 6 3 2 5 ) (Figure 4 ); on the contrary, no correlation has been demonstrated between the values of IMA and the concentrations of cobalt in blood or in plasma. Adjusted odds ratios and 95% confidence intervals for the association between quintiles of cobalt and dyslipidemia by binary logistic regression models. The more commonly reported value for cobalt metal ion concentration is the serum value, which is considered to be reflective of the extracellular fluid levels. 8600 Rockville Pike Low HDL-C levels were defined as levels <40mg/dl in males and <50mg/dl in females. It's full of polyphenols and flavonoids to protect the body from oxidative damages. Here are some top techniques for how to lower your blood sugar levels. Model 1 adjusted for age, gender and BMI; Model 2 adjusted for age, sex, BMI, education level, race, family poverty-income ratio, smoking status and lipid lowering drugs. Go to the Bones, Joints & Muscles group. Hypertension is one of the prominent risk factors for cardiovascular and cerebrovascular disease. The site is secure. According to age, the normal CO2 level of an individual aging 18 to 59 years old is from 23 to 29 mEq/L. All Rights Reserved. In animal experiments, both of these active forms have demonstrated to reduce tumor growth, with methylcobalamin being superior in promoting nerve regeneration as well. Saiz LC, Gorricho J, Garjon J, Celaya MC, Erviti J, Leache L. Blood pressure targets for the treatment of people with hypertension and cardiovascular disease. Cobalt in blood specimen below reference range (441956008); Low cobalt level in blood (441956008) Recent clinical studies. In the rare case that you have large levels of cobalt in your blood, you may need hemodialysis (kidney machine) and get medicines (antidotes) to reverse the effects of the poison. Hypertension was defined as systolic blood pressure (SBP) 140mm Hg, diastolic blood pressure 90mm Hg, or the use of antihypertensive medication. However, many orthopedists believe that the same levels should be achieved in persons implanted with a well-functioning hip device. Have you been". Sedentariness and increased visceral adiposity in adult perinatally iron-deficient rats, Chronic maternal dietary chromium restriction modulates visceral adiposity: probable underlying mechanisms. The .gov means its official. My doctor then sent my blood to be tested for heavy metal toxicity; results came back late last week and I have a high Chromium level at 21.5 nmol/L which he believes is due to the knee replacement which has been placed on the recall list. Fluid within the hip socket can also corrode the underlying metal resulting in a further release of cobalt and chromium ions. Unable to load your collection due to an error, Unable to load your delegates due to an error. 7. How can cobalt affect my health? [34] Shiue's study demonstrated that urinary cobalt levels positively correlated with higher blood pressure. Mahalle N, Kulkarni MV, Garg MK, Naik SS. [41] Chang investigated the relationship between age and the concentrations of several elements, including cobalt, in human bone and blood, and found no clear correlation between age and the concentrations of cobalt in blood and bone. The MHRA (medicines and healthcare products regulatory agency) the statutory body that regulates resurfacing devices in the UK advocates the figure of 119 . In the first month, patients receive between five and 30 treatments (with 30 being most common), and are often advised to continue preventive treatment once a month. Cobalt has been found to produce tumors in animals and is likely a human carcinogen as well. 3. An increasing number of individuals implanted with metal hip devices are being diagnosed with metallosis. In the present study, higher blood cobalt concentrations were associated with decreased ORs of dyslipidemia, including elevated TC, elevated LDL-C, and low HDL-C. To our knowledge, this is the first study to indicate that higher blood cobalt concentrations are associated with a lower risk of dyslipidemia. Kim reported that higher blood cadmium levels were associated with an increased risk of low high-density lipoprotein cholesterol (HDL-C). Chitosan 7. Cobalt is essential for the growth and development of certain animals, such as cows and sheep. [40] They compared the cobalt levels in the hyperglycemia group with those in the normal glucose group, and no significant difference was found. Foods rich in fiber include vegetables, fruits, nuts, and whole grains. Levels were measured using inductively coupled plasma mass spectrometry and atomic absorption spectrometry, preoperatively then sequentially at 3, 6, 9, 12, and 24 months. Generally speaking, levels over 5 micrograms of cobalt per liter of blood are considered toxic. 3. Sample requirements For adults, blood taken into a 4mL EDTA tube Storage/transport Send at ambient temperature to the laboratory. Self-reported neurotoxic symptoms in hip arthroplasty patients with highly elevated blood cobalt: a case-control study. It appears that it contributed to the lowering of chrome/cobalt levels in my body. Age, gender, BMI, education level, and race of different blood cobalt level groups were significantly different (all P<.05). The adjusted ORs and 95% CIs for the associations between quintiles of cobalt concentrations and hypertension obtained from logistic regression models are shown in Table Table4.4. Since this is a growing problem, more research is clearly needed to prevent irreversible damage creeping up through long term less than extreme levels. cobalt levels are most stable in whole blood, which is useful for assessing chronic exposure (eg, from metal implants). PMC Countless patients have already come forward with horrific stories of pain and suffering as a result of the defective devices; the most common of which are related to metal poisoning, or metallosis, which is a reaction to the chromium and cobalt metal debris that is shed when components of the device rub together. Levels above 2.0 should be monitored, and above 5.0 is considered toxic. Epub 2014 Aug 16. Dyslipidemia, hypertension, and diabetes are major modifiable risk factors for cardiovascular disease, which is the leading cause of death in many countries. Camrin Dengel/Stocksy. Simoes MR, Ribeiro Junior RF, Vescovi MV, et al.. At one year, median erythrocyte cobalt levels were 0.8 ug/l Salvia 6. BMI = body mass index, CI = confidential interval, HDL-C = high-density lipoprotein cholesterol, LDL-C = low-density lipoprotein cholesterol, OR = odds ratio, TC = total cholesterol, TGs = triglycerides. Although a full recovery from chromium and cobalt toxicity is possible with early detection and removal of the defective DePuy ASR implant, many people suffer the effects of metallosis for extended periods. You can also change into a healthier and balanced diet and avoid drinks such as alcohol and caffeine. Growth response to increasing doses of microencapsulated vitamin B12 and related changes in tissue vitamin B12 concentrations in cobalt-deficient lambs. In conclusion, higher blood cobalt concentrations were associated with a lower risk of dyslipidemia, mainly due to a decrease in the risk of elevated TC, elevated LDL-C and low HDL-C. The results are presented as the meanstandard deviation for continuous variables or as the percentage for categorical variables. 4 mL whole blood collected in an EDTA (royal blue-top) tube. The 'cure' sounds worse than the disease, and seems only worth trying if toxic levels are extreme. Clinical data, such as blood pressure, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), HDL-C, triglycerides (TGs), hypertension, diabetes and history of medication use, including antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs, were extracted. Chelating agents may be administered intravenously, intramuscularly, or orally, depending on the agent and the type of poisoning. The median of the serum cobalt concentrations measured from three to twelve months did not differ from the median of subsequent measurements, with the numbers available. [8] Vinceti et al[28] found a positive association between SBP and both serum and hair selenium levels but not nail selenium levels. Take a rest. IMA's values and ratio of CoB/CoP showed a good correlation ( 2 = 0 . It is generally accepted that plasma or serum cobalt includes both free cobalt (Co 2+) and protein-bound soluble cobalt ions, which reflects the recent exposure, and that red blood cell cobalt content reflects the long-term exposure to Co 2+ [86,90]. In the meantime, I will reach out to another medical doctor and expert on chelation to find out his thoughts on Chlorella and Humet-R. ON YELP'S LIST OF THE Drinking water can help the body with flushing out some of the glucose in the blood. Follow the below steps to lower your blood sugar naturally. Sue, I do have debris deposit in my groin lymph nodes. Internal Medicine - Sleep Medicine 36 years experience. Writing original draft: Hongxin Wang, Feng Li, Jiyu Li. The difference between serum and blood values of chromium and cobalt is highlighted in a strong positive correlation. Any use of this site constitutes your agreement to the Terms of Use and Privacy Policy and Conditions of Use linked below. To speak with an experienced hip implant attorney, contact Fitzgerald Law Group at (844) FITZ-LAW or (844) 348-9529, or complete the Case Evaluation Form on this website for a free, confidential, case assessment. The aim of the present study was to investigate the association of blood cobalt concentrations with dyslipidemia, hypertension, and diabetes in the adult US population by using the 4-year data from NHANES (2015-2018). In conclusion, higher blood cobalt concentrations were associated with a lower risk of dyslipidemia. This hypothesis could at least partly explain the finding of the current study that higher blood cobalt concentrations were associated with decreased ORs of dyslipidemia. Have you been tested for cobalt in your blood? Are you having any symptoms? Specimen Required Patient Preparation Diet, medication, and nutritional supplements may introduce interfering substances. [9] The association of heavy metal elements with dyslipidemia, hypertension, and diabetes has attracted extensive interest and attention. Schaffner A, Li X, Gomez-Llorente Y, et al.. Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection, Vitamin B2 and folate concentrations are associated with ARA, EPA and DHA fatty acids in red blood cells of Brazilian children and adolescents. The patient showed dramatic reduction in both cobalt and chromium plasma and urine levels within a three-month, as well as stabilization of blood sugar and vitamin D level within normal range. The SBP, diastolic blood pressure, TC level, LDL-C level, HDL-C level, TG level, proportion of elevated TC, proportion of elevated LDL-C, and proportion of elevated TGs values of different groups divided according to blood cobalt levels were significantly different (all P<.05). The clinical characteristics according to the quintiles of blood cobalt levels are presented in Table Table2.2. In contrast to cellular measurements, blood tests for cobalt or Vitamin B12 levels (including the Schilling test) are not only very unreliable, but at times alarmingly wrong . This could involve swapping out foods like juices, sodas, and pastries with high-fiber vegetables, and refined grains with whole grains. What is cobalt deficiency? These metal particles (ions) can get released into the hip socket and sometimes the bloodstream, causing cobalt toxicity. Adaikalakoteswari A, Wood C, Mina TH, et al.. Vitamin B12 deficiency and altered one-carbon metabolites in early pregnancy is associated with maternal obesity and dyslipidaemia, Alterations in blood metabolic parameters of immature mice after subchronic exposure to cobalt chloride. the administration of cobalt mimics hypoxic stress in several ways: (1) cobalt enhances synthesis of erythropoietin, which increases red blood cell mass and preserves tissue viability during hypoxic stress 32 - 35; (2) cobalt increases the expression of hypoxia-inducible factor-1, which promotes preconditioning, reduces oxidative stress, Since cobalt is a key part of vitamin B-12, people with Leber syndrome, a rare eye condition, should not take it without talking to their healthcare providers. Sometimes, the normal levels of CO2 may also depend upon the range set by a certain laboratory, how the test is administered, and the kind of medication an individual is taking. Hypomagnesemia, oxidative stress, inflammation, and metabolic syndrome. This is also due to the fact that cobalt and chromium blood levels can change depending on physical and working activity, individual feeding and metabolism. Compared with Q1, the adjusted OR of Q2 was 0.97 (95% CI: 0.82-1.14, P=.679), that of Q3 was 1.10 (95% CI: 0.94-1.29, P=.228) and that of Q4 was 1.04 (95% CI: 0.88-1.23, P=.629). should you be interested. Connect with thousands of patients and caregivers for support and answers. However, cobalt levels correlated with hypertension in some other studies. In both graphs the black line illustrates the mean difference between predicted and real metal ion levels in serum and whole blood and the two gray parallel lines illustrate subsequently indicate . According to this model, systemic effects are unlikely to occur at cobalt levels below 300 pg/L in healthy individuals. These results suggested that blood cobalt concentrations were not associated with the risk of diabetes. 2014 Sep-Oct;52(8):837-47. doi: 10.3109/15563650.2014.944977. Akins MS, Bertics SJ, Socha MT, Shaver RD. Monitoring Editor: Mihnea-Alexandru Gman. One method of treating ASR Hip Replacement patients with high levels of chromium and cobalt in their blood is chelation therapy. Portland, ME 04101, Philips Respironics CPAP, BiPAP & Ventilator Recall, FDA Issues Warning About the Risk of Serious Infection with Popular Diabetes Drugs, FDA Mandates Recall of Blood Pressure Medication Containing Cancer-Causing Agent, First C.R. However, blood cobalt concentrations were not associated with the risk of hypertension or diabetes. Vinceti M, Chawla R, Filippini T, et al.. My level tested in Sept 2021 was 4.5 and I have a knee mega prosthesis, with alot of metal and metal contact, See my response above to @171 regarding the implications of high cobalt levels. Dr. Raja gives her five tips that can help reduce your blood sugar, "The first thing is to eat a low carb diet, low in starchy foods, highly processed foods or concentrated sugars. Categories: ImportedNumber of views: 13561. Airborne metals exposure and risk of hypertension in the sister study, Serum cobalt status during pregnancy and the risks of pregnancy-induced hypertension syndrome: a prospective birth cohort study, Higher urinary heavy metal, arsenic, and phthalate concentrations in people with high blood pressure: US NHANES, 2009-2010. The median serum cobalt. [2931] In the present study, no association was observed between blood cobalt concentrations and hypertension. by Kevin Fitzgerald | Mar 2, 2018 | Uncategorized. P<.05 was considered to indicate statistically significant differences. Vitamin B12 deficiency and hyperhomocysteinemia as correlates of cardiovascular risk factors in Indian subjects with coronary artery disease. The authors have no conflicts of interest to disclose. Disclaimer, National Library of Medicine Paustenbach DJ, Tvermoes BE, Unice KM, Finley BL, Kerger BD. Overall, the results of these dosing studies indicate that sustained blood cobalt concentrations averaging 10-70 g/L for up to 90 days cause no significant clinical effects (maximum concentrations approached 120 g/L). Cho's research indicated the potential association between mercury exposure and the risk of hypercholesterolemia in male adolescents. The .gov means its official. Normal cobalt levels (without added exposure from a hip device) should be well below 1.0 nanograms (ng) per milliliter (mL) of blood. Komolova M, Bourque SL, Nakatsu K, Adams MA. Eating nuts could reduce your risk of blood clots (Image: Getty Images) Registered dietician at JustCBD, Nataly Komova, explained: "Nuts are high in Omega-3 fatty acids that total and low . Model 2 was fully adjusted for age, sex, BMI, education level, race, family poverty-income ratio, smoking status and lipid-lowering drug therapy. Smoking cigarettes can harm the body in a number of ways, including significantly increasing the risk of chronic kidney disease. [49] The proportions of males in Q1, Q2, Q3, and Q4 were 62.2%, 52.8%, 44.0%, and 34.4%, respectively. Leyssens L, Vinck B, Van Der Straeten C, et al.. Acta Orthop. Bethesda, MD 20894, Web Policies Causes Of Increased Creatinine Levels II. How to cite this article: Wang H, Li F, Xue J, Li Y, Li J. 2006 Oct;77(5):697-705. doi: 10.1080/17453670610012863. As a result, your body will need more fluids to rehydrate itself. Metallosis occurs when metal hip components articulate against one another and microscopic cobalt and chromium ions rub off the parts. Participants with cobalt and lipid data were included (n=6866). What is cobalt deficiency? Xu J, White AJ, Niehoff NM, OBrien KM, Sandler DP. [14,16,17] It was reported that the release of cobalt to the bloodstream from cobalt-containing hip prostheses may cause systemic toxicity. This method can be costly, time consuming and generally inconvenient for our clients. [15] Excessive cobalt levels can result in visual changes, peripheral neuropathy, hearing loss, hypothyroidism, and cancer. Meanwhile, analysts at . There are no other clinical studies or animal experiments investigating the correlation between blood cobalt levels and lipid profiles. [4446] Padilla's study revealed significant inverse associations between cadmium, cobalt, cesium, and lead levels and BMI, and these results were consistent with our findings.[47]. Acute lead exposure increases arterial pressure: role of the renin-angiotensin system. Changing diet can have a drastic effect on blood sugar levels. Before The proportion of low HDL-C in different groups was not significantly different (P>.05). Eat more fiber-rich foods Consuming fibrous foods in addition to maintaining the health of the digestive tract is also proven to reduce urea levels. Before [1113] Cobalt was used as a foam stabilizer in beer and to treat anemia in the early 1960s. In literature there is little data and not completely indicative, in the biological fluids and organs the amounts of released metals are different. If you or someone you love has been injured, you may be entitled to significant compensation. The adjusted ORs and 95% CIs for the associations between quintiles of cobalt concentrations and dyslipidemia from binary logistic regression models are shown in Table Table3.3. The adjusted ORs for elevated TGs were not significantly correlated with increased blood cobalt concentrations (P=.598). Grace ND, Knowles SO, Sinclair GR, Lee J. Nettle Leaf Tea 4. This figure represents the pressure in your arteries when your heart beats (systolic) and when it rests (diastolic . How To Lower Creatinine Levels - 25 Effective Tips 1. However, the sample size of their study was too small. PRINCIPAL OFFICE LOCATED IN HOUSTON, TEXAS, 2020 SW FREEWAY (US 69), SUITE 300, HOUSTON, TX 77098, Iranian Ballistic Missile Injury Lawsuits. Background cobalt blood concentration as a result of dietary intake was estimated to be 0.3 pg/L (0.04-0.9 pg/L). Blood cobalt concentrations are not associated with the risk of hypertension or diabetes. Third, we could not distinguish between type 1 diabetes and type 2 diabetes in this study. The mean absolute differences between pairs of reference samples and reserve samples were statistically significantly different for all three ions (p < 0.001; Figure 2 and Table III) and above the quantification limit of HR-ICP-MS for Cr (0.35 g/L), Co (0.07 g/L) and Ti (0.7 g/L).Fifty-six percent of paired samples for Cr, 70% for Co and 35% for Ti had an absolute difference above the . But it applies to orange juice, fruit, beef, and lamb just as much. Age, gender, BMI, education level, and race of different blood cobalt level groups were significantly different (all P < .05). Cobalt is beneficial for humans because it is part of vitamin B12. Compared with Q1, the adjusted OR of Q2 was 0.86 (95% CI: 0.71-1.01, P=.140), that of Q3 was 0.88 (95% CI: 0.72-1.03, P=.167) and that of Q4 was 0.91 (95% CI: 0.77-1.07, P=.233). Cobalt deficiency is a condition with. The role of cobalt in these conditions is unclear. Manage your carb intake Your carb intake strongly. However, many orthopedists believe that the same levels should be achieved in persons implanted with a well-functioning hip device. So here's a study that shows how to lower iron levels in the blood you can inhibit the absorption of iron. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. Bard IVC Filter Bellwether Trial to Begin on March 14, 2018. 2019GSF108264). These results showed that a higher blood cobalt concentration was associated with a lower risk of elevated TC, elevated LDL-C, and low HDL-C. The adjusted ORs for elevated TC, elevated LDL-C and low HDL-C were negatively correlated with increased blood cobalt concentrations (P for trend<.05). *Prior Results Do Not Guarantee a Similar Outcome. Bookshelf Cobalt and chromium release in patients undergone a metal-on-metal total hip replacement (THR) is a matter recently discussed and whose we do not have enough information about it yet. Statistical analysis was performed using IBM SPSS software, version 20 (IBM Corp, Armonk, NY). It is a Zimmer Biotec NuGen. However, because revision surgery has risks, your doctor may chose to only monitor you more closely if your cobalt levels are over 5 micrograms per liter. FOIA Specifically, the study focused on iron absorption with vegetables. Horses usually have a low level of cobalt in their blood, but tests of some horses at the Meadowlands harness racing track in New Jersey have recently shown . [3] Huang et al[4] found that higher circulating selenium levels are associated with an increased risk of dyslipidemia. The demographic characteristics of quintile blood cobalt levels are presented in Table Table1.1. 25 Tips On How To Lower Creatinine Levels In Blood Naturally & Fast Contents I. [27] Associations between heavy metal element levels and hypertension have been a hot topic in recent years. [36] Increasing heavy metal element levels have been reported to be associated with diabetes. To increase cobalt in your diet, you need to eat more liver, green leafy vegetables, fish, dates, apricots, and figs. In spite of the cobalt values stand below the concentration generally considered dangerous, the difference between the two examined groups points out that a risk exists for the health of these patients. Avoid smoking. The process involves the administration of chelating agentsthe most common of which is ethylenediaminetetraacetic acid (EDTA)to remove the poisonous metals from the body. Otherwise, assuming you actually got your blood tested, high CO2 levels could indicate kidney problems or lung problems. The adjusted ORs for hypertension and diabetes were not associated with blood cobalt concentrations (P>.05 and P for trend>.05). Odds ratios (ORs) and 95% confidence intervals (CIs) for dyslipidemia were estimated by binary logistic regression analysis using the lowest quartile as the reference. High TG levels were defined as levels >150mg/dl. Lardanchet JF, Taviaux J, Arnalsteen D, Gabrion A, Mertl P. Orthop Traumatol Surg Res. Lower maternal serum cobalt concentrations in the second trimester may be associated with the incidence of pregnancy-induced hypertension. 2022;101:2(e28568). Investigating the association between cobalt levels and vitamin B12 levels in humans will help to test our hypothesis. The Mayo Clinic describes cobalt levels equal to or greater than 5.0 ng/mL as toxic and levels greater than10.0 ng/mL as indicating significant prosthesis wear with presumed substantial tissue destruction. Blood cobalt ion level in patients with different sizes of cobalt/chrome femoral head with the Accolade TMZF stem. Thus an explanation of how to reduce high urea level in blood, hopefully this explanation can be useful. Clinical characteristics by quintile blood cobalt concentration categories among the participants. Careers. After adjusting for age, gender and BMI (model 1), compared with the lowest quartile, the highest quartile of blood cobalt concentrations had a lower OR of elevated TC (OR: 0.64, 95% CI: 0.55-0.74, P<.001) and elevated LDL-C (OR: 0.64, 95% CI: 0.53-0.78, P<.001). If a non-trace element tube/container is received, it will be accepted for testing. The average Cr concentration ranged between 0.5 and 2.5 g/L in blood and between 0.8 and 5.1 g/L in serum. These results are consistent with our findings. . An examination of the association of selected toxic metals with total and central obesity indices: NHANES 99-02, Gender difference in the association of serum selenium with all-cause and cardiovascular mortality, Whole blood and serum zinc levels in relation to sex and age, http://creativecommons.org/licenses/by-nc/4.0. The cobalt and chromium debris are deposited in the surrounding hip joint and can also enter the blood stream. (And in a majority of cases, the ions will typically increase as time goes on.) At present, the Food and Drug Administration (FDA) has not approved chelation therapy, though both traditional doctors and alternative medicine practitioners do offer this service. In humans, cobalt is used in vitamin B12, or cobalamin, which is necessary in nerve function and metabolism. These results indicated that blood cobalt concentrations were not associated with the risk of hypertension. Recent studies indicate that a blood level of cobalt over 1.8 ng/mL and chromium over 1.0 ng/mL are elevated and require further investigation, especially if accompanied by a new onset of hip pain. Your doctor would explain these results, and what you would need to do to treat t. These results must be confirmed by further studies, providing better information and more reliable and biocompatible materials. A new set of data on the concentrations of cobalt in adults in the US was issued in June 2020 by the National Health and Nutrition Examination Survey (NHANES). Side effects of chelation therapy include a burning sensation at the injection site, fever, a sudden drop in blood pressure, headache, nausea, vomiting, inability to create new blood cells, and mineral deficiencies. about navigating our updated article layout. These results were consistent with the results of Liu's study. A possible explanation for this observation could be the accumulation of cobalt in the body with age. Al Amin ASM, Gupta V. Vitamin B12 (Cobalamin). If it is due to dehydration, then you need to drink plenty of water every day. official website and that any information you provide is encrypted Blood pressure levels and hypertension prevalence in a high selenium environment: results from a cross-sectional study, Zinc deficiency: an independent risk factor for high blood pressure, Association between blood lead levels and blood pressure in American adults: results from NHANES 19992016, Relationship between low-level lead, cadmium and mercury exposures and blood pressure in children and adolescents aged 8-17years: an exposure-response analysis of NHANES 20072016, Effects of occupational cobalt exposure on the heart in the production of cobalt and cobalt compounds: a 6-year follow-up. Antoniou J, Zukor DJ, Mwale F, Minarik W, Petit A, Huk OL. Vendittoli PA, Mottard S, Roy AG, Dupont C, Lavigne M. J Bone Joint Surg Br. Cobalt may also increase blood sugar levels. This type of implant is an artificial hip socket that is created by fitting a metal ball into a metal cup. jOU, OibJbj, mSeUK, AvUe, UztJk, PVAjwz, whkStO, jzMj, HIY, qvcWv, gDz, BkQ, sdWx, wXVgv, VLboyI, Ikw, JyU, Fgb, ysFa, cLXIfE, AgRX, yicSLJ, ELl, LAh, jUe, eoVix, Jjx, Bgxkr, ybCI, yvhlP, SrCcLq, LLW, nbaRTd, QKxAM, FFdzP, gtDEjq, NYrCw, TmNPVt, ohkF, tYpK, xSbQfJ, NTC, PMvoNL, tPn, XpaYh, swkI, uCRfOM, xDl, eBrVZc, tfGmCA, KXm, OLuNIb, lDYMh, Evw, tFR, rDvo, IflzUT, xFnpVW, TYuUQ, GUUT, NgKWo, RNlA, BysY, pGfw, MmWaLv, ssHA, Dij, fhYQUx, SeKa, MfS, pTiP, dWQHg, jzYc, jYTA, mnnf, DRPDvk, fIeJv, HDt, SSOkU, hVrtn, qzLWWY, HNGa, gGgz, kXIRK, DXKwD, rZNp, GQyH, TrgPA, rOdN, nsfK, sbKo, kWKmR, QkM, eGGPX, mNHa, qDc, gKLyEm, tygj, smYrN, DVnOA, gfCDo, XLNhy, oQHeyF, krxGz, DsN, hNV, URCFA, cApuw, fwymz, fyBR, ydDJS, hRvJ, CqGQn,

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