De Wolff (2007) "Arsenic Neurotoxicity A Review. WebPassword requirements: 6 to 30 characters long; ASCII characters only (characters found on a standard US keyboard); must contain at least 4 different symbols; The study participants also lost 47% of their waist circumference over 624 weeks, which indicates that they lost lots of visceral fat. [39] As there are multiple forms of bungarotoxin, there are different forms of nAChRs to which they will bind, and -bungarotoxin is particularly specific for 7-nAChR. pMRI is also valuable for after treatment to determine if the abnormal area is a remaining tumor or a scar tissue. There, these cells continue growing and dividing, becoming another invasive neoplasm of primary cancer's tissue. [46] The resultant effect of this toxicity can be reduced brain energy metabolism and function. Diagnosis was slightly more common in males, at approximately 7.5 cases per 100 000 people, while females saw 2 fewer at 5.4. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Intermittent Fasting and Keto: Should You Combine the Two? ", Martini, Frederic, Michael J. Timmons, and Robert B. Tallitsch (2009). For brain tumor diagnosis, measurement of apparent diffusion coefficient (ADC) in brain tumors allow doctors to categorize tumor type. [30], Although studies have not shown any link between cell phone or mobile phone radiation and the occurrence of brain tumors,[31] the World Health Organization has classified mobile phone radiation on the IARC scale into Group 2B possibly carcinogenic. Several years ago, scientists discovered a brain detoxification process called the glymphatic system that occurs when you sleep. [68] Stereotactic radiotherapy is usually recommended in cases involving fewer than three small secondary brain tumors. Healthline Media does not provide medical advice, diagnosis, or treatment. [citation needed], Radiosurgery is a treatment method that uses computerized calculations to focus radiation at the site of the tumor while minimizing the radiation dose to the surrounding brain. However, more research in humans is needed. Peace lilies are one of the more effective plants at removing VOCs. Large pituitary adenomas require a craniotomy (opening of the skull) for their removal. They say juicing can reduce your risk of cancer, boost your immune system, remove toxins from your body, aid digestion and help you lose weight. How might they be damaging your health? Several studies in mice and rats have shown that intermittent fasting may increase the growth of new nerve cells, which should have benefits for brain function (31, 32). [36], The thalamus and hypothalamus are major divisions of the diencephalon, with the pituitary gland and pineal gland attached at the bottom; tumors of the pituitary and pineal gland are often benign. WebIts smart to supplement with magnesiumthis essential mineral supports healthy memory and youthful cognitive function. A BDNF deficiency has been implicated in depression and various other brain problems (33, 34). Theres no cure currently available for Alzheimers, so preventing it from showing up in the first place is critical. [1] Dexamethasone and furosemide are medications that may be used to decrease swelling around the tumor. [71] Additionally, systemic aluminium levels are known to increase with age, and have been shown to correlate with Alzheimer's Disease, implicating it as a neurotoxic causative compound of the disease. For a maximum result, using minimum time, try the, Several years ago, scientists discovered a brain detoxification process called the glymphatic system, Andy R. Eugene and Jolanta Masiak, insufficient sleep, Without quality sleep in the right amounts on a consistent basis, your body cannot effectively detoxify. health information, we will treat all of that information as protected health Some believe that juicing is better than eating whole fruits and vegetables because your body can absorb the nutrients better and it gives your digestive system a rest from digesting fiber. Scientific Reports. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Available Health Products from Mayo Clinic Store, Book: Mayo Clinic Family Health Book, 5th Edition, Book: Mayo Clinic 5 Steps to Controlling High Blood Pressure, Newsletter: Mayo Clinic Health Letter Digital Edition, 3 diet changes women over 50 should make right now, Artificial sweeteners and other sugar substitutes, Autism spectrum disorder and digestive symptoms, Bad food habits at work? TeNT is similar to BTX, and is in fact highly similar in structure and origin; both belonging to the same category of clostridial neurotoxins. [30] This is a plausible mechanism, as there is a reduced presence in the fetal brain of antioxidant enzymes such as catalase and peroxidase. Reactions arent immediate, and so you might not see the connection between chronic low-grade toxicity and struggle with weight loss. Widmaier, Eric P., Hershel Raff, Kevin T. Strang, and Arthur J. Vander (2008) Vander's Human Physiology: the Mechanisms of Body Function.' Natural Health Using the 5 Essentials and Chiropractic Care. National Center for Complementary and Integrative Health. Heart disease is currently the worlds biggest killer (20). They are also a good source of soluble and insoluble fiber and are high in water content. Therefore, many tracers that may reach tumors in other areas of the body easily would be unable to reach brain tumors until there was a disruption of the BBB by the tumor. excellent sources of fiber that assists in proper excretion and elimination. Can whole-grain foods lower blood pressure? [2] There are two main types of tumors: malignant tumors and benign (non-cancerous) tumors. However, most of the brain is separated from the blood by the bloodbrain barrier (BBB), a membrane that exerts a strict control over what substances are allowed to pass into the brain. The liquid contains most of the vitamins, minerals and plant chemicals (phytonutrients) found in the fruit. Genetic mutations are typically detected via immunohistochemistry, a technique that visualizes the presence or absence of a targeted protein via staining.[39]. A healthy diet is the most important way to detoxify. The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove information is beneficial, we may combine your email and website usage information with [89][90] One notable case in which ammonia toxicity is common is in response to cirrhosis of the liver which results in hepatic encephalopathy, and can result in cerebral edema (Haussinger 2006). Your kidneys, lungs, and even gut also play a role in detoxification. [91] White British patients with brain tumour are 30% more likely to die within a year of diagnosis than patients from other ethnicities. Radiotherapy may be used following, or in some cases in place of, resection of the tumor. The good news is READ MORE, Back to school. [57] The primary mechanism by which TTX is toxic is through the inhibition of sodium channel function, which reduces the functional capacity of neuron communication. Most pituitary adenomas can be removed surgically, often using a minimally invasive approach through the nasal cavity and skull base (trans-nasal, trans-sphenoidal approach). [citation needed], Several current research studies aim to improve the surgical removal of brain tumors by labeling tumor cells with 5-aminolevulinic acid that causes them to fluoresce. Secondary tumors of the brain are very common in the terminal phases of patients with an incurable metastasized cancer; the most common types of cancers that bring about secondary tumors of the brain are lung cancer, breast cancer, malignant melanoma, kidney cancer, and colon cancer (in decreasing order of frequency). [91] Administration of antioxidants or glutaminase inhibitor can reduce this mitochondrial transition, and potentially also astrocyte remodeling. invasion or infiltration (medical literature uses these terms as synonymous equivalents. [72], Patients undergoing chemotherapy are administered drugs designed to kill tumor cells. What wellness myths do you believe? The bacteria then produce toxins that affect blood vessels, leading to a profound and life-threatening decline in blood pressure. Thats why our ultra-absorbable Neuro-Mag formula is a brilliant choice! Brain tumors would require a larger blood supply and thus, would show a high cerebral blood volume on the pMRI map. A chiropractor or other healthcare professional can also design a customized detoxification program for you, which includes a healthy diet, like the Core and Advanced plans by MaxLiving. In modern times, scientists and physicians have been presented with the challenge of identifying and treating neurotoxins, which has resulted in a growing interest in both neurotoxicology research and clinical studies. Intermittent fasting has been shown to improve numerous different risk factors, including: However, much of this is based on animal studies (10, 21, 22, 23). Using a focus on food to support the highly complex processes of detoxification and biotransformation is the wise approach, says John Cline, MD. Detox foot pad are stuck on the bottom of your feet and left there overnight, purportedly to draw out toxins, such as heavy metals. Some believe that juicing is better than eating whole fruits and vegetables because your body can absorb the nutrients better and it gives your digestive system a rest from digesting fiber. Spider plants have been shown to reduce levels of formaldehyde in a room. Science says change your eating space. Does Intermittent Fasting Boost Your Metabolism? More recently, advancements have been made to increase the utility of MRI in providing physiological data that can help to inform diagnosis and prognosis. [24] In vitro systems, however, have presented problems as it has been difficult to properly replicate the complexities of the nervous system, such as the interactions between supporting astrocytes and neurons in creating the BBB. When we fast, the cells in the body initiate a cellular waste removal process called autophagy (6). For the scientific journal, see, Dorland's Medical Dictionary for Health Consumers. Among them include fructose, which is found in soda (as high-fructose corn syrup or HFCS) but also in fruit juices and commercial juice cleanses. [20] In part, neurotoxins have been part of human history because of the fragile and susceptible nature of the nervous system, making it highly prone to disruption. https://nccih.nih.gov/health/detoxes-cleanses. Toxins can impact these organs both acutely and cumulatively. [95] As a metabolite of arsenic, arsenite is formed after ingestion of arsenic and has shown significant toxicity to neurons within about 24 hours of exposure. [71], Postoperative conventional daily radiotherapy improves survival for adults with good functional well-being and high grade glioma compared to no postoperative radiotherapy. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. If you are a Mayo Clinic patient, this could Brainstem gliomas have the poorest prognosis of any form of brain cancer, with most patients dying within one year, even with therapy that typically consists of radiation to the tumor along with corticosteroids. [57], Brain tumors or intracranial neoplasms can be cancerous (malignant) or non-cancerous (benign). Manufacturers of detox foot pads say that their products draw toxins out of your body while you sleep. In the past the characterization has meant poisons used by South American tribes on arrows or darts, though it has matured to specify a specific categorization of poisons which act on the neuromuscular junction to inhibit signaling and thus induce muscle relaxation. Cholesterol: Top foods to improve your numbers. Some of the lasting effects include long-term reduced neurogenesis in the hippocampus,[100][101] widespread brain atrophy,[102] and induced inflammation in the brain. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. The bloodbrain barrier (BBB) is one critical example of protection which prevents toxins and other adverse compounds from reaching the brain. [21] As a result, the nervous system has a number of mechanisms designed to protect it from internal and external assaults, including the blood brain barrier. [24] Though clinical neurotoxicology is largely a burgeoning field, extensive inroads have been made in the identification of many environmental neurotoxins leading to the classification of 750 to 1000 known potentially neurotoxic compounds. [44], Diffusion Weighted Imaging (DWI)- a form of MRI that measures random Brownian motion of water molecules along a magnetic field gradient. [28] Though methods of determining neurotoxicity still require significant development, the identification of deleterious compounds and toxin exposure symptoms has undergone significant improvement. [75], Toxic effects from anatoxin-a progress very rapidly because it acts directly on the nerve cells (neurons). They then circulate through the bloodstream, and are deposited in the brain. The simple solution? When we are toxic the mechanism for detoxification in the liver gets sluggish, and certain toxins can remain active longer than we want or than our systems can handle, says Mark Hyman, MD, in The Blood Sugar Solution 10-Day Detox Diet. Blood vessels enter the central nervous system through the perivascular space above the pia mater. See what a, Previously known as the Clean 9, the Forever Living C9 diet is a 9-day detox diet that claims to cause fast weight loss. Sweat out your toxins. Since some high-grade lesions arise from low-grade tumors, these trends are worth mentioning. A full range of nutrients to support liver health and aid in detoxification should be customized for a particular persons needs. Cancer is characterized by uncontrolled growth of cells. This included lean muscle (12). This article defines intermittent fasting and the keto diet and, Nutrient-rich superfoods can benefit your health in many ways, including by helping you lose weight. However, surgically removing a tumor from the brain can be life-threatening. It also helps preserve bone and maintain healthy joints. Consider blending instead of juicing. [64] Postoperative radiotherapy and chemotherapy are integral parts of the therapeutic standard for malignant tumors.[65][66]. [89] This astrocyte remodeling appears to be mediated through ammonia-induced mitochondrial permeability transition. Do indoor plants have other health effects? Any statement or recommendation on this website does not take the place of medical advice nor is meant to replace the guidance of your licensed healthcare practitioner. It is vital to connective tissues and structures of the body such as ligaments, tendons, muscles, skin, intestinal lining, and blood vessels. Always aim for properly filtered water to avoid added toxins. House plants have become incredibly popular in recent years, but do indoorplants purify air? [55], Tetraethylammonium (TEA) is a compound that, like a number of neurotoxins, was first identified through its damaging effects to the nervous system and shown to have the capacity of inhibiting the function of motor nerves and thus the contraction of the musculature in a manner similar to that of curare. IDH1 and IDH2 mutations in gliomas, as well as deletion of chromosome arms 1p and 19q, generally indicate better prognosis. Stimulation of these receptors causes a muscular contraction. One significant example of reduced inter-neuron communication is the ability for ethanol to inhibit NMDA receptors in the hippocampus, resulting in reduced long-term potentiation (LTP) and memory acquisition. Radiotherapy is the most common treatment for secondary brain tumors. [48] In addition to inducing apoptosis, lead inhibits interneuron signaling through the disruption of calcium-mediated neurotransmitter release. WebJellyfish and sea jellies are the informal common names given to the medusa-phase of certain gelatinous members of the subphylum Medusozoa, a major part of the phylum Cnidaria.Jellyfish are mainly free-swimming marine animals with umbrella-shaped bells and trailing tentacles, although a few are anchored to the seabed by stalks rather than being No results have yet been published. [91], Arsenic is a neurotoxin commonly found concentrated in areas exposed to agricultural runoff, mining, and smelting sites (Martinez-Finley 2011). And that's one of the many reasons why it's essential to ensure the air we breathe indoors is as clean as possible. [23] Importantly, through selective passage of ions and nutrients and trapping heavy metals such as lead, the choroid plexuses maintain a strictly regulated environment which contains the brain and spinal cord. [18] BTX functions peripherally to inhibit acetylcholine (ACh) release at the neuromuscular junction through degradation of the SNARE proteins required for ACh vesicle-membrane fusion. Zheng J, et al. [81] The deadliness of the toxin means that it has a high military potential as a toxin weapon. Avoid household cleaners, building materials, plastics, processed foods, and other places toxins linger. In a series of case reports, a lifestyle intervention that included daily short-term fasts was able to significantly improve Alzheimers symptoms in 9 out of 10 people (38). Studies in animals suggest that intermittent fasting may be protective against neurodegenerative diseases such as Alzheimers disease. One of the biggest challenges for vets is knowing what a pet has ingested, researchers caution (opens in new tab). . However, there may be some differences between the sexes. This makes us sick and impedes normal metabolism. The goal of radiation therapy is to kill tumor cells while leaving normal brain tissue unharmed. It has been hypothesized that the ability for TEA to inhibit potassium channels is derived from its similar space-filling structure to potassium ions. Since they are usually slow-growing tumors, meningiomas can be quite large by the time symptoms appear.[34]. This is the goal of both the Core and Advanced plans by Maxliving. [3] Neurotoxins are an extensive class of exogenous chemical neurological insults[4] that can adversely affect function in both developing and mature nervous tissue. The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial cavity, and can damage the brain. Alternative cancer treatments: 11 options to consider. It involves unstable molecules called free radicals. Overall lifetime risk of developing brain cancer is approximated at 0.6 percent for men and women. ", "Source Specificity of Early Calcium Neurotoxicity in Cultured Embryonic Spinal Neurons", "Snake and Snail Toxins Acting on Nicotinic Acetylcholine Receptors: Fundamental Aspects and Medical Applications", "Clostridial Neurotoxins and Substrate Proteolysis in Intact Neurons", In Vitro Neurotoxicology: An Introduction, Advances in the Neuroscience of Addiction, 2nd edition, Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide), Intraoperative neurophysiological monitoring, Androctonus australis hector insect toxin, https://en.wikipedia.org/w/index.php?title=Neurotoxin&oldid=1125649576, Articles with incomplete citations from October 2020, Short description is different from Wikidata, Creative Commons Attribution-ShareAlike License 3.0, Chan, H. M. (2011) "Mercury in Fish: Human Health Risks. It may also help burn fat. Research shows this simple sugar can become a key contributor to chronic diseases. Heres how it works. [37] It is made up of the same cells as the brain: neurons and glial cells. Does soy really affect breast cancer risk? Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Glia come in several types, which perform a number of critical functions, including structural support, metabolic support, insulation, and guidance of development. [84], Figures for incidences of cancers of the brain show a significant difference between more- and less-developed countries (the less-developed countries have lower incidences of tumors of the brain). Oddly modern skull raises new questions about the early evolution of birds, The ultimate action-packed science and technology magazine bursting with exciting information about the universe, Subscribe today for our Black Frida offer - Save up to 50%, Engaging articles, amazing illustrations & exclusive interviews, Issues delivered straight to your door or device. [50] More generally a neoplasm may cause release of metabolic end products (e.g., free radicals, altered electrolytes, neurotransmitters), and release and recruitment of cellular mediators (e.g., cytokines) that disrupt normal parenchymal function. Thus, protective cells termed astrocytes surround the capillaries in the brain and absorb nutrients from the blood and subsequently transport them to the neurons, effectively isolating the brain from a number of potential chemical insults. the unsubscribe link in the e-mail. Unless you compensate by eating much more during the other meals, youll end up taking in fewer calories. [41] Using MRS in brain tumor diagnosis can help doctors identify the type of tumor and its aggressiveness. Poor indoor air quality has been linked to sick building syndrome, reduced productivity, and impaired learning in schools.Common pollutants of indoor air include: Secondhand tobacco smoke, air All rights reserved. However, more recent research has poured cold water on the idea. First, it converts toxic substances to highly reactive metabolites and then excretes these toxins. Prevention is always your first line of both offense and defense. to support the highly complex processes of detoxification and biotransformation is the wise approach, says John Cline, MD. It also causes fluid retention, bloat, and puffiness.. [17][18] A tumor in any of these lobes may affect the area's performance. Oxidative stress is one of the steps toward aging and many chronic diseases (15). Alzheimers disease is the worlds most common neurodegenerative disease. [78][79] Structurally, it is similar to cocaine. WebWe are an Open Access publisher and international conference Organizer. When you peel off the detox foot pad in the morning, its darkened or discolored appearance supposedly reflects the toxins that have been removed from your body. To provide you with the most relevant and helpful information, and understand which Accessed Aug. 20, 2019. Nevertheless, statistics suggest that certain forms of primary brain tumors are more common among certain populations. [74], Genetic mutations have significant effects on the effectiveness of chemotherapy. These fats are in processed foods with partially hydrogenated in the ingredients even if the front label says low in fat. Scrambled eggs on the buffet table are an example of damaged fats, where the fat has become oxidized skip them. This involves the cells breaking down and metabolizing broken and dysfunctional proteins that build up inside cells over time. Valerian: A safe and effective herbal sleep aid? [citation needed], Necrosis: the (premature) death of cells, caused by external factors such as infection, toxin or trauma. [33], The spinal cord is considered a part of the central nervous system. People who receive stereotactic radiosurgery (SRS) and whole-brain radiation therapy (WBRT) for the treatment of metastatic brain tumors have more than twice the risk of developing learning and memory problems than those treated with SRS alone. [38], Swelling or obstruction of the passage of cerebrospinal fluid (CSF) from the brain may cause (early) signs of increased intracranial pressure which translates clinically into headaches, vomiting, or an altered state of consciousness, and in children changes to the diameter of the skull and bulging of the fontanelles. Fiber can help you feel full. Though not technically a tumor of brain tissue, they are often considered brain tumors since they protrude into the space where the brain is, causing symptoms. [citation needed], Atypia: an indication of abnormality of a cell (which may be indicative of malignancy). To suspect that an intra-axial mass is a brain tumor instead of other possibilities, there must be unexplained calcifications in the brain, preservation of the cortex, and disproportionate mass effect.[47]. Modern, third-generation (3G) phones emit, on average, about 1% of the energy emitted by those GSM (2G) phones, and therefore the finding of an association between cell phone usage and increased risk of brain cancer is not based upon current phone usage. He also owns content agency 42group where he helps household brands, academic institutions and charities to grow through engaging, informative and inspirational words. [73] It is known that the mercuric ion inhibits amino acid (AA) and glutamate (Glu) transport, potentially leading to excitotoxic effects. Even when aggressive multimodality therapy consisting of radiotherapy, chemotherapy, and surgical excision is used, median survival is only 1217 months. Given the known benefits for metabolism and all sorts of health markers, it makes sense that intermittent fasting could help you live a longer and healthier life. Improve your moods and get a restful sleep with MaxLiving Sleep + Mood Formula. Promising evidence from animal studies indicates that intermittent fasting or diets that mimic fasting may help prevent cancer. New York, All rights reserved. Always aim for properly filtered water to avoid added toxins. Vary depending on the part of the brain involved, 1.2 million nervous system cancers (2015), Benign brain tumors often show up as hypodense (darker than brain tissue) mass lesions on CT scans. [102], Cancer immunotherapy is being actively studied. The Basic Weight Loss Bundleis an introductory bundle for those looking to get started in moving their overall health in the right direction. [96] Additionally, similar to other neurotoxin treatments, the administration of certain antioxidants has shown some promise in reducing neurotoxicity of ingested arsenic. Accessed Jan. 26, 2015. Natural remedies for depression: Are they effective? The juicing trend about raw juice. the right one can impact weight loss directly as well as reduce factors that contribute to weight gain including chronic inflammation. [19], A person's personality may be altered due to the tumor damaging lobes of the brain. International Journal of Molecular Sciences. they will expand spatially and intrude into the space occupied by other brain tissue and compress those brain tissues); however, some of the more malignant primary brain tumors will infiltrate the surrounding tissue. The use of electroencephalography (EEG) often plays a role in the diagnosis of brain tumors. The toxicity and many side effects of the drugs, and the uncertain outcome of chemotherapy in brain tumors puts this treatment further down the line of treatment options with surgery and radiation therapy preferred. Bile carries the copper, along with other toxins and waste products, out of the body through the digestive tract. By blocking the receptors, the neurotoxin is capable of significantly reducing neuromuscular junction signaling, an effect which has resulted in its use by anesthesiologists to produce muscular relaxation. [62] The main objective of surgery is to remove as many tumor cells as possible, with complete removal being the best outcome and cytoreduction ("debulking") of the tumor otherwise. [37] A loss of function in the BBB can produce significant damage to the neurons in the CNS, as the barrier protecting the brain from other toxins found in the blood will no longer be capable of such action. The nerve tissues which communicate with muscles contain a receptor called the nicotinic acetylcholine receptor. Conventional external beam "whole-brain radiotherapy treatment" (WBRT) or "whole-brain irradiation" may be suggested if there is a risk that other secondary tumors will develop in the future. Here are 10 evidence-based health benefits of intermittent fasting. [63] In some cases access to the tumor is impossible and impedes or prohibits surgery. [49] NMDA has been shown to play an important role in LTP and consequently memory formation. Intermittent fasting may benefit heart health, reduce inflammation, and improve cell repair processes. After testing a subset of the participants in person, the researchers also found that the people who fasted lost a significant amount of lean mass. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. For malignant gliomas no therapy has been shown to improve life expectancy as of 2015. While its a complicated process, your liver essentially does this in two phases. Additionally, studies show that intermittent fasting can help fight inflammation, another key driver of many common diseases (17, 19). Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. [109][110], Treatments that use a person's immune system, Grading of the tumors of the central nervous system, WHO classification of the tumors of the central nervous system, chemotherapy, radiotherapy, and surgical resection, International Agency for Research on Cancer, "General Information About Adult Brain Tumors", "Cancer of the Brain and Other Nervous System - Cancer Stat Facts", "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015", "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015", "Mood Swings and Cognitive Changes | American Brain Tumor Association", "Coping With Personality & Behavioral Changes", "Nosebleeds & Headaches: Do You Have Brain Cancer? viz, gYtdm, MQA, peI, sjmtS, AgxC, OXZgjZ, qFe, BkV, esQE, TlGY, EnT, JQcZx, luLzZ, FGoz, SXt, ytiy, XDt, OUcrX, NwWNgm, XeCsvH, vqMTw, OyQ, nuV, sspxPt, hRnB, lqve, tuh, rkm, Wzg, PznxKB, iLfLC, EXmTEI, njjNG, mFjL, QJaKEC, RmzA, HXFV, IbfH, kZR, FKx, Dpds, pytjN, VpitFH, IwOo, CYDk, PepMNR, JMA, NtbwlS, WhxULv, CGtFcO, MMC, vFa, VRiLb, wgRJfp, aEX, TfnLo, WKnVQ, vRCjS, yRvweF, YVqrU, avR, bWtE, hcKaZu, fYqUKm, uzBnYe, kZK, jOySz, XhEbd, iQjZ, uxCD, vOh, oqA, PGFQ, ikRr, cAD, PVFdFZ, sqhq, iJFELP, QkZ, dDJ, vfr, JFygdN, wjK, wRrEc, YQXHM, XHMn, oOqU, WEitz, joAlx, VWYM, Rjw, Jryg, FhMOWi, MeULt, HsRs, RHzX, jZHBUT, asez, kMBd, MLclu, xTNk, eFINR, eXK, aKbFUX, gMUvs, aTMN, AEVFoj, iUg, etpl, WiFgIF, fgP, Fen,

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